Table 1.

Multiple reactions monitoring parameters for the detection of prasugrel, prasugrel active metabolite, prasugrel active metabolite-d3, midazolam, omeprazole, bupropion and flurbiprofen

Compounds	Polarity	Q1→Q3 (m/z)	CE (V)	DP (V)	Dwell time (ms)	LLQ (ng/ml)
Prasugrel	+	374→206	23	100	2	0.5
Prasugrel AM1	+	498→348	28	100	2	0.5
Prasugrel AM-d31	+	501→348	25	150	2	0.5
Midazolam	+	326→291	37	165	2	0.1
Omeprazole	+	346→198	19	66	2	0.5
Bupropion	+	240→131	30	80	2	0.5
Flurbiprofen	+	243→199	18	50	2	100

CE, collision energy; DP, declustering potential; LLQ, lower limit of quantification.

¹Compounds derivatized with 2-bromo-3-methoxyacetophenone (BMAP).