Figure 7. Noxa induction is associated with increased apoptosis caused by the combined treatment of PEITC and CDDP in HeLa cells.
A, Immunoblot analysis of levels of Bcl-2, Bcl-xL, Bax, PUMA, Noxa, Bcl-xL, DR4, DR5, and TRAIL proteins in whole-cell lysates of cells after treatment with PEITC, CDDP or their combination for 8 to 24 h. B, MEK1 inhibitor U0126 partially inhibited Noxa protein level induced by the combined treatement of PEITC and CDDP.