Figure 3. Antigen delivery with α-DEC and α-Langerin mAbs is more efficient than α-DCIR2 and α-Treml4 for the generation of MOG-specific Foxp3⁺ T cells.

(A) Dose response of MOG-specific Foxp3⁺ T cell generation in sLN (left) and spleen (right). Recipient mice transferred with 4 × 10⁶ MOG-specific CD4⁺ T cells 1 day before s.c. inoculation of α-receptor–MOGp mAbs were analyzed 7 days later. Mean ± SEM of 3–5 experiments, with a total of 6–10 mice per group. (B) As in A, but comparison of different inoculation routes: s.c. via footpad, i.p., i.v., and i.m. Mean ± SEM of 4–8 mice per group in 2–4 experiments.