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. 2013 Jan 9;123(2):800–811. doi: 10.1172/JCI60139

Figure 7. TP inhibited keratin retraction and loss of cell adhesion induced by anisomycin-mediated p38 MAPK activation.

Figure 7

(A) Anisomycin-induced p38 MAPK activation after 6 hours was blocked by the specific p38 MAPK inhibitor SB202190, but not by simultaneous TP treatment n = 3. (B) Keratin retraction by anisomycin was inhibited by both SB202190 and TP. Scale bar: 20 μm. (C) Statistical analysis of keratin retraction from 6 independent experiments with 5 fields of view each. *P < 0.05 vs. DMSO; #P < 0.05 vs. anisomycin. (D) Loss of cell adhesion by anisomycin was prevented by both SB202190 and TP as detected by dispase-based dissociation assays. n = 9. *P < 0.05 vs. DMSO; #P < 0.05 vs. anisomycin.