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. 2013 Jan 9;123(2):812–822. doi: 10.1172/JCI64093

Figure 1. Impact of spironolactone treatment on plasma biochemical parameters and on survival of kl/kl mice.

Figure 1

Arithmetic mean ± SEM (n = 4–17) of (A) plasma calcium concentration (mg/dl), (B) plasma inorganic phosphate concentration (mg/dl), (C) plasma FGF23 concentration (pg/ml, (D) plasma calcitriol concentration (pmol/l), (E) body weight (g), (F) systolic blood pressure (mmHg), (G) plasma urea nitrogen concentration (mg/dl), and (H) plasma cystatin C concentration (ng/ml) in WT mice (white bars) and kl/kl mice (kl/kl; black bars), treated with control solution (Ctr) or spironolactone (Spr). ##P < 0.01, compared with kl/kl mice; *P < 0.05, **P < 0.01, ***P < 0.001, compared with WT control-treated mice. (I) Kaplan-Meier blot showing survival of kl/kl mice (black line; n = 13) and kl/kl mice treated with spironolactone (kl/klspr; gray line; n = 12; P < 0.01). Four mice were censored due to end of observational period.