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. 2013 Jan 25;123(2):740–750. doi: 10.1172/JCI66911

Figure 5. Degeneration of OHC, but not IHC, in cochlea of Nesp4–/– and Sun1–/– mice.

Figure 5

(A) SEM at P0, P15, P30, and P60 reveals a mid to apical gradient of degeneration in the OHC of Nesp4–/– mice. Three rows of OHCs and 1 row of IHCs are present in WT mice, whereas the OHC degeneration is apparent by P15 in the mutant mice. The IHC remain intact at these ages. P0, n = 4/4; P15, n = 5/5; P30, n = 5/5; P45, n = 4/4; P60, n = 5/5. (B) At P30, degeneration of OHC, but not IHC, is apparent in Sun1–/– mice comparable to that observed in the Nesp4–/– mice. P30,WT, mut n = 4. Scale bars: 10 μm.