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. 2013 Jan 16;123(2):903–907. doi: 10.1172/JCI66227

Figure 1. PP-treated animals have increased expression of APC-related genes.

Figure 1

(A) Top 200 genes based on P value for contrast between RNA extractions from colonic CD45+ leukocytes from animals treated with ARV alone (left) and animals treated with ARV+PP (right). The complete linkage method was used for hierarchical cluster analysis. Rows, normalized expression value for single genes; columns, each sample; red, upregulated; blue, downregulated gene expression based on Z-score (see legend below). (B) Fold change of selected upregulated genes in colonic leukocytes in animals treated with ARV+PP (top) or ARV alone (bottom). P values are indicated over each bar. (C) Frequency of HLA-DR+CD45+, live APCs in the colon. (D) MFI of HLA-DR on live CD45+ APCs. (E) Percentages of live, HLA-DR+CD45+ APCs in the colon producing IL-23 after mitogenic stimulation. Circles, ARV+PP-treated PTM with suppressed viremia; squares, ARV+PP-treated slow responder PTM; triangles, ARV-alone–treated PTM. Horizontal bars represent median. All data analyzed from necropsy samples (∼day 315 after SIV).