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(A) CSCs are regulated by androgen-independent pathways, involving α6β4 integrin that amplifies signaling through ErbB2 and c-Met pathways, which can be inhibited by lapatinib and crizotinib. (B) Bulk tumor cell growth is primarily regulated by androgens through interaction with AR and is sensitive to androgen blockade. Androgen signaling inhibits expression of Erbb2 and c-Met.
