Table I.

Experimentally characterized activities of selected N6P SF enzymes

		Enzymatic Activity
Protein Accession ID	Subgroup	Lactonase	Esterase	Organophosphatase	SS
Rauvolfia serpentina strictosidine synthase (pdb_id: 2fpb, 2fpc, 2fp8, 2pf9, 2vaq, 2v91)	SSL	?(a)	?	?	Yes(b) [8]
Catharanthus roseus strictosidine synthase (GI:18222)	SSL	?	?	?	Yes [9]
Ophiorrhiza pumila strictosidine synthase (GI:13928598)	SSL	?	?	?	Yes [10]
Ophiorrhiza japonica strictosidine synthase (GI: 193792547)	SSL	?	?	?	Yes (Predicted)(d) [13]
Rauvolfia mannii strictosidine synthase (GI: 21097)	SSL	?	?	?	Yes (Predicted)(d) [11]
Rauvolfia verticillata strictosidine synthase (GI: 118076220)	SSL	?	?	?	Yes (Predicted)(d) [12]
Homo sapiens adipocyte plasma membrane-associated protein (APMAP) (GI: 24308201)	SSL	?	Yes [32]	?	?
PON1 G2E6 mutant (pdb_id: 1v04)	Arylesterase	Yes [55]	Yes [55]	Yes [55]	?
Homo sapiens paraoxonase 1 (PON1) (GI: 130675)	Arylesterase	Yes [18]	Yes [18]	Yes [18]	?
Homo sapiens paraoxonase 2 (PON2) (GI: 6174935)	Arylesterase	Yes [18]	Yes [18]	No(c) [18]	?
Homo sapiens paraoxonase 3 (PON3) (GI: 29788996)	Arylesterase	Yes [18]	Yes [18]	Yes [18]	?
Loligo vulgaris diisopropyl flurophosphatase (DFPase) (pdb_id: 1e1a, 1pjx, 2gvv, 2gvw, 3byc)	SGL	No [19]	?	Yes [69]	?
Fusarium oxysporum lactonohydrolase (GI: 6448475)	SGL	Yes [27]	?	No [7]
Rattus norvegicus senescence marker protein-30 (regucalcin) (GI: 68067383)	SGL	Yes [23]	Yes [24]	Yes [24]	?
Staphylococcus aureus drug responsive protein 35 (Drp35) (pdb_id: 2dg0, 2dg1, 2dso)	SGL	Yes [25]	?	?	?
Zymomonas mobilis gluconolactonase (GI: 48655)	SGL	Yes [66]	?	?	?

^(a)No available literature reference showed that this activity was detected: “?”,

^(b)detected activity: “Yes”,

^(c)no detectable activity: “No”,

^(d)Based on similarities to experimentally characterized SSs (see text): “Yes (Predicted)”.