Figure 6.

R283K pol β ternary complex with a templating anti-8-oxoG and incoming dAMPCPP. The templating anti-8-oxoG, incoming dAMPCPP and α-helix (Helix) N are shown in green. Mn²⁺ and water molecules are shown as red and blue spheres, respectively. (A) Active site of the R283K pol β anti-8-oxoG:dAMPCPP with a F_o − F_c map (green) contoured at 3σ. (B) Key active site hydrogen bonding interactions between the templating anti-8-oxoG and incoming dATP are shown with black dashes. The key amino acids are shown in stick format and the octahedral geometry for each metal ion is illustrated.