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. 2013 Jan 28;136(1):28–42. doi: 10.1093/brain/aws322

Figure 3.

Figure 3

CR3/43 versus CD68 immunoreactivity in the corpus callosum in a case of long-term survival after TBI. (A) Dense CR3/43 reactive microglia with an amoeboid morphology in a 37-year-old male, 4 years post-injury. CR3/43 is an major histocompatibility complex Class II specific antibody and as such binds to the cell surface as can be observed. Scale bar = 100 µm. (B) The same region in this case displays a virtually identical cell population when subjected to immunohistochemistry specific for CD68. In contrast to CR3/43, CD68 immunoreactivity is predominantly intracellular, given that it is a lysosomal protein. Scale bar = 100 µm. (C–D) Low magnification photomicrographs displaying CR3/43 and CD68 immunoreactivity, respectively, in the same case as above. Cells tend to form bands along the inferior and superior border of the corpus callosum. Scale bar = 200 µm.