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. 2013 Feb 1;8(2):e55414. doi: 10.1371/journal.pone.0055414

Figure 2. Altered expression in a network of Ras/MAPK associated signaling pathway genes in TCC progression.

Figure 2

The stimulatory and inhibitory interactions of gene products differentially expressed in T1–T4 versus Ta tumors were mapped based on KEGG pathway maps. Node color denotes relative expression: Yellow = Increased expression in muscle-invasive tumors; Blue = Decreased expression in muscle-invasive tumors. Green and red arrows represent stimulatory and inhibitory interactions, respectively. The names of genes with supported associations with muscle-invasive tumors are highlighted in bold italics.