Table 2. KEGG pathway enrichment of genes differentially expressed in T1–T4 staged bladder tumors versus Ta-stage tumors.
| KEGG Pathway | Number of Pathway Genes in Dataset | Enrichment Factor “R” | Fisher's Exact, Adjusted P-value |
| All Changes, Top 10 | |||
| Metabolic pathways | 332 | 3.46 | 5.26E-93 |
| Cell cycle* | 68 | 6.11 | 2.46E-36 |
| Spliceosome | 68 | 6.11 | 2.46E-36 |
| DNA replication | 29 | 9.27 | 3.29E-23 |
| Pyrimidine metabolism | 47 | 5.52 | 1.05E-22 |
| Ubiquitin mediated proteolysis | 54 | 4.50 | 6.33E-21 |
| Pathways in cancer* | 86 | 3.00 | 2.50E-19 |
| Focal adhesion* | 63 | 3.61 | 1.30E-18 |
| Huntington's disease | 60 | 3.73 | 1.32E-18 |
| Purine metabolism | 52 | 3.96 | 1.75E-17 |
| Selected Pathways | |||
| MAPK signaling pathway* | 60 | 2.57 | 6.88E-11 |
| ErbB signaling pathway* | 26 | 3.44 | 5.92E-08 |
| Bladder cancer* | 16 | 4.38 | 7.25E-07 |
| Genes Up, Top 10 | |||
| Metabolic pathways | 299 | 3.57 | 1.64E-85 |
| Spliceosome | 66 | 6.79 | 1.34E-37 |
| Cell cycle* | 62 | 6.38 | 2.13E-33 |
| DNA replication | 29 | 10.61 | 7.10E-25 |
| Pyrimidine metabolism | 46 | 6.18 | 3.64E-24 |
| Ubiquitin mediated proteolysis | 50 | 4.77 | 3.54E-20 |
| Huntington's disease | 58 | 4.13 | 7.22E-20 |
| Purine metabolism | 51 | 4.45 | 3.88E-19 |
| Oocyte meiosis | 42 | 4.85 | 1.95E-17 |
| Alzheimer's disease | 50 | 3.91 | 4.12E-16 |
| Parkinson's disease | 43 | 4.26 | 1.71E-15 |
| Genes Down, Top 10 | |||
| Complement and coagulation cascades | 11 | 14.12 | 1.22E-08 |
| Pathways in cancer* | 21 | 5.64 | 1.22E-08 |
| Focal adhesion* | 17 | 7.49 | 1.22E-08 |
| MAPK signaling pathway* | 17 | 5.60 | 4.00E-07 |
| Small cell lung cancer | 10 | 10.54 | 8.56E-07 |
| Metabolic pathways | 35 | 2.81 | 1.07E-06 |
| p53 signaling pathway | 9 | 11.55 | 1.31E-06 |
| Tight junction | 11 | 7.27 | 5.35E-06 |
| NOD-like receptor signaling pathway | 8 | 11.43 | 5.84E-06 |
| Metabolism of xenobiotics by cytochrome P450 | 8 | 10.12 | 1.36E-05 |
(*)
indicates KEGG pathways that involve mechanisms of signal transduction. P value represents the results of Fisher's Exact tests reported by WebGestalt.