Table 4. Average normalized median expression of selected genes differentially expressed in non-invasive and muscle-invasive TCC in at least 3 datasets within the Oncomine Collection.

	Gene	Average Change in Median (Fold Increase vs Superficial)	St.Dev.	Mann-Whitney Rank-Sum p =	References
Validated	COL3A1	3.99	2.29	0.028	[16]–[21]
	COL5A1	5.07	1.74	0.047	[15]–[17], [19], [20]
	COL11A1	3.37	2.30	0.025	[15]–[17], [19]–[21]
	FN1	5.45	2.25	0.028	[16], [17], [19]–[21]
	CDC25C	1.48	1.43	0.08	[15]–[17], [19]–[21]
	MAPK10	0.55	1.70	0.08	[15]–[17], [19]–[21]
	ERBB3	0.45	1.77	0.072	[16], [17], [19]–[21]
Rejected	AKT3	1.64	2.02	0.305	[15]–[17], [19]–[21]
	DUSP14	1.53	1.26	0.105	[16], [17], [19]–[21]
	FAS	1.43	1.49	0.236	[15]–[17], [19], [21]
	COL1A1	3.72	2.52	0.101	[16]–[20]
	COL1A2	2.26	2.73	0.288	[16]–[20]
	CDC25B	1.53	1.54	0.189	[15]–[21]
	CDK6	1.53	1.36	0.189	[15]–[17], [19]–[21]
	TGFBR1	1.24	1.41	0.443	[16], [17], [19], [20]
	CDC27	1.17	1.42	0.222	[15]–[17], [19]–[21]
	IKBKB	0.76	1.25	0.148	[15], [16], [19]–[21]
	ERBB2	0.71	1.65	0.417	[15]–[17], [19]–[21]
	SMAD3	0.69	1.76	0.202	[15]–[19], [21]
	PRKCD	0.58	1.65	0.202	[15]–[17], [19], [20]
	CXCL6	2.96	1.99	0.156	[15], [16], [19]–[21]
	CXCL14	1.02	1.35	0.5	[16], [19], [20]
	INSR	1.05	1.36	0.115	[15]–[17], [19], [21]

Genes selected based on significance (p<0.05) or near-significance (p<0.10) as determined by one-sided Mann-Whitney Rank-Sum tests. “References” contain the citations of the studies from which data analyzed by Oncomine were derived.