Table 1.
Physiological parameters
|
Groups |
CTL |
STZ |
STZ + HEME |
||||||
|---|---|---|---|---|---|---|---|---|---|
| day 0 | day 30 | day 60 | day 60 | day 30 | day 60 | day 60 | day 30 | day 60 | |
|
BW, g |
278 ± 14 |
364 ± 24 |
436 ± 17 |
264 ± 10 |
241 ± 15* |
255 ± 20* |
247 ± 5 |
213 ± 18* |
226 ± 18* |
|
Uv, ml |
13 ± 2 |
14 ± 1 |
12 ± 1 |
13.1 ± 1 |
69 ± 11* |
57 ± 18* |
16 ± 2 |
83 ± 5* |
86 ± 2* |
|
BG, mg/dl |
86 ± 4 |
113 ± 12 |
109 ± 2 |
84 ± 4 |
470 ± 24* |
554 ± 29* |
80 ± 3 |
557 ± 27* |
338 ± 24*# |
|
U, mg/dl |
45 ± 3 |
47 ± 4 |
44 ± 2 |
48 ± 2 |
91 ± 11* |
88 ± 8* |
48 ± 2 |
70 ± 5* |
59 ± 6*# |
|
ClCr, ml/min |
- |
- |
1.02 ± 0.07 |
- |
- |
0.12 ± 0.03* |
- |
- |
0.28 ± 0.02*# |
|
UA, mg/24h |
0.50 ± 0.08 |
0.33 ± 0.06 |
0.28 ± 0.04 |
0.81 ± 0.09 |
1.67 ± 0.98 |
3.50 ± 1.04* |
0.42 ± 0.05 |
1.05 ± 0.63 |
0.85 ± 0.42 |
| UNaV, mEq/24h | 0.7 ± 0.1 | 0.8 ± 0.1 | 0.7 ± 0.1 | 0.7 ± 0.1 | 2.8 ± 0.8* | 0.9 ± 0.3 | 1.0 ± 0.1 | 2.4 ± 0.5* | 1.4 ± 0.2* |
Data were expressed as the mean ± SEM. The significance level for a null hypothesis was set at 5% (p < 0.05). BW (body weight), Uv (urinary volume), BG (blood glucose), U (serum urea), ClCr (creatinine clearance), UA (urinary albumin) and UNaV (urinary sodium excretion) were analyzed in CTL, STZ and STZ+HEME groups. (*) versus CTL and (#) versus STZ.