. 2013 Jan 2;6:1. doi: 10.1186/1756-6606-6-1

Table 1.

Basic channel properties, activators and inhibitors of ASICs

Gene	Protein	pH₅₀	Agonist (EC₅₀)	Antagonist (IC₅₀)	Ions passed	References
ASIC1 (ACCN2)	ASIC1a	6.2–6.8	MitTx (9.4 nM)	PcTx1 (~1 nM)	Na⁺ > Ca²⁺	[5,12,13,22-27]
				Mambalgin (55 nM)
				Sevanol (2.2 mM)
				A-317567 (2 μM)
	ASIC1b	~6.0 (mouse)	MitTx (23 nM)	Mambalgin (192 nM)	mouse: Na⁺ human: Na⁺ > Ca²⁺	[6,7,12,13,22,24,28]
		~6.2 (human)
ASIC2 (ACCN1)	ASIC2a	4.5–4.9	Minimal activa-tion by MitTx	A-317567 (29 μM)	Na⁺	[12,15,22,25,29-31]
	ASIC2b	N/A			--	[29-31]
ASIC3	ASIC3	~6.6	GMQ (0.35 mM)	APETx2 (63 nM)	Na⁺	[13,22,25,32-36]
			MitTx (830 nM)	Sevanol (0.35 mM)
				A-317567 (9.5 μM)
ASIC4	ASIC4	N/A			--	[37]
Heteromeric channels	1a + 1b	6.0		Mambalgin (72 nM)	Na⁺	[15]
	1a + 2a	5.5–6.1		Mambalgin (246 nM)	Na⁺	[12,15,24,26]
	1a + 2b	Same as ASIC1a		Mambalgin (61 nM) PcTx1 (~3 nM)	Na⁺ > Ca²⁺	[9,15,24]
	1a + 3	6.3–6,6			Na⁺	[12,15]
	1b + 3	6.0			Na⁺	[15]
	1b + 2a	4.9			Na⁺	[15]
	2a + 3	5.7–6.1			Na⁺	[12,15]
	2b + 3	6.5		APETx2 (117 nM)	Na⁺	[15,33,36]

Note: amiloride is not included in the table because it functions as a universal blocker for ASICs and many other ion channels, such as ENaCs and sodium/hydrogen exchangers.