Table 3.
Association of tumor GFRα1, GFRα3 and SDC3 protein expression with clinicopathologic parameters of patients with mammary carcinoma
| |
GFRα1 expression (n (%)) |
GFRα3 expression (n (%)) |
SDC3 expression (n (%)) |
||||
|---|---|---|---|---|---|---|---|
| Parameter | n | protein | P | protein | P | protein | P |
|
Age (years) | |||||||
| ≤ 35 |
16 |
9 (56.3) |
0.249 |
9 (56.3) |
0.078 |
5 (31.3) |
0.768 |
| 35-55 |
92 |
34 (37.0) |
|
26 (28.3) |
|
24 (26.1) |
|
| > 55 |
51 |
17 (33.3) |
|
15 (29.4) |
|
16 (31.4) |
|
|
Tumor size (cm) | |||||||
| ≤ 2 |
13 |
6 (46.2) |
0.135 |
4 (30.8) |
0.37 |
5 (38.5) |
0.555 |
| 2 ~ 5 |
115 |
38 (33.0) |
|
33 (28.7) |
|
30 (26.1) |
|
| > 5 |
31 |
16 (51.6) |
|
13 (41.9) |
|
10 (32.3) |
|
|
Histologic type | |||||||
| Ductal |
150 |
57 (38.0) |
0.142 |
49 (32.7) |
0.352 |
41 (27.3) |
0.313 |
| Lobular |
6 |
2 (33.3) |
|
1 (16.7) |
|
2 (33.3) |
|
| Mucinous |
3 |
1 (33.3) |
|
0 (0) |
|
2 (66.7) |
|
|
Lymph node metastasis | |||||||
| 0 |
55 |
9 (16.4) |
0.001 |
9 (16.4) |
0.006 |
15 (27.3) |
0.977 |
| 1 ~ 3 |
55 |
24 (43.6) |
|
19 (34.5) |
|
16 (29.1) |
|
| >3 |
49 |
27 (55.1) |
|
22 (44.9) |
|
14 (28.6) |
|
|
Grade | |||||||
| I |
13 |
6 (46.2) |
0.657 |
4 (30.8) |
0.906 |
4 (30.8) |
0.788 |
| II |
102 |
36 (35.2) |
|
31 (30.4) |
|
27 (26.5) |
|
| III |
44 |
18 (40.9) |
|
15 (34.1) |
|
14 (31.8) |
|
|
Stage | |||||||
| I-II |
85 |
19 (22.4) |
0.001 |
19 (22.4) |
0.008 |
23 (27.1) |
0.709 |
| III-IV |
74 |
41 (55.4) |
|
31 (41.9) |
|
22 (29.7) |
|
|
ER status^ | |||||||
| - |
94 |
39 (41.5) |
0.24 |
27 (28.7) |
0.374 |
24 (25.5) |
0.351 |
| + |
65 |
21 (32.3) |
|
23 (35.4) |
|
21 (32.3) |
|
|
PR status^^ | |||||||
| - |
90 |
32 (35.6) |
0.517 |
28 (31.1) |
0.917 |
22 (24.4) |
0.218 |
| + |
69 |
28 (40.6) |
|
22 (31.9) |
|
23 (33.3) |
|
|
HER-2 * | |||||||
| - |
121 |
40 (33.1) |
0.03 |
31 (25.6) |
0.005 |
33 (27.3) |
0.607 |
| + | 38 | 20 (52.6) | 19 (50.0) | 12 (31.6) | |||
^ ER positive required at least 10% staining nuclei.
^^ PR positive required at least 10% staining nuclei.
HER-2 positive were 3+ or 2+ and FISH confirmed.
Values in bold are significant (P < 0.05).