Table 5: Select Bone morphogenetic proteins: properties, indications and product examples.

	Alternate Names	FDA Approved Indications	Osteoinductive Properties	Angiogenic Properties	Comments	Commercial Products	Price25
BMP-1					A metalloproteinase (only BMP not from TGF-β family). May induce cartilage formation in vivo26
BMP-2		Approved for ALIF and acute open tibia fracturesa	+	+7	Only BMP to induce osteoblastic differentiation of MSCs7	Infuseb	$3500-4900
BMP-3					No demonstrated osteoinductive activity
BMP-4			+		Overexpressed in Fibrodysplasia Ossificans Progressiva27
BMP-6			+		May play a role in iron regulation through effect of iron regulatory hormone, hepcidin28
BMP-7	Human Osteogenic Protein-1	Approved (HDE only) for revision PLIF and long bone nonunionsc	+	+7		OP-1d	$5,000
BMP-14	rhMP52, GDF-5, CDMP-120		+		Animal models demonstrate equal or better efficacy than autograft in ALIF procedures. May play a role in embryonic limb differentiation.20

^a ALIF, anterior lumbar interbody fusion; ^bInfuse (Medtronic Sofamor Danek); ^cHDE, humanitarian device exemption; PLIF, posterior lumbar interbody fusion; ^dHuman Osteogenic Protein-1 (OP-1, Stryker Biotech)