Figure 6. Expression levels of CSN6 and p57 in breast cancer samples and their correlations with survival. (A) A large percentage of breast cancer samples have high CSN6 and low p57. Cell lysates from 25 primary human breast cancer samples were immunoblotted with indicated antibodies. (B) Kaplan-Meier analysis showed that high expression of CSN6 and low expression of p57 were associated with poor overall survival. The expression levels of CSN6 and p57 were investigated by immunohistochemical staining, and were correlated with the overall survival rate. (C) Model of how CSN6-mediated p57 degradation affects cell proliferation, cell cycle progression and cell transformation.