Table 1.
Clinical outcome measures for FTD clinical trials
| Domain | Clinical Syndromes | Data collected from | Test | Longitudinal Data in FTD? | Reference |
|---|---|---|---|---|---|
| General Cognitive | bvFTD, SD, PNFA, CBS, PSPS | Patient | Addenbrooke's Cognitive Examination –Revised (ACE-R) | Yes | 1 2 3 4 |
| bvFTD, SD, PNFA | Patient | Mini Mental State (MMSE) | Yes | 5,6 | |
| Executive function | bvFTD, SD, PNFA, CBS, PSPS | Patient | EXAMINER | Yes | 7 |
| bvFTD | Informant | Frontal Systems Behavior Evaluation (FrSBe) | No | 8 | |
| bvFTD, SD, PNFA, CBS, PSPS | Patient | Frontal Behavior Inventory | Yes | 6,9,10 | |
| ADL, IADL | bvFTD, SD, PNFA | Informant | Disability Assessment for Dementia (DAD) | Yes | 11 12 |
| bvFTD, SD, PNFA, | Informant | Clinical Dementia Rating Scale (CDR) | Yes | 5 | |
| bvFTD, SD, PNFA | Patient | Test of Everyday Functional Activities (TEFA) | Yes | 6 | |
| General | bvFTD, SD, PNFA, PSPS | Informant and Patient | Clinicians Global Impression of Change (CGIC)/Clinical Global Impression of Severity (CGIS) | Yes | 5,13 |
| Multiple Domains | bvFTD, SD, PNFA | Informant | Frontotemporal Dementia Rating Scale (FRS) | Yes | 14 |
| Neuropsychi atric | bvFTD, SD, PNFA, CBS, PSPS | Both | Neuropsychiatric Inventory (NPI) | Yes | 6 |
| bvFTD, SD, PNFA | Informant | Cambride Behavior Inventory | No | 15 | |
| Motor | bvFTD, SD, PNFA, CBS, PSPS | Patient | Unified Parkinson's Disease Rating Scale | Yes | 6 |