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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Neuropharmacology. 2012 Dec 4;67C:337–348. doi: 10.1016/j.neuropharm.2012.11.026

Figure 5.

Figure 5

A: Mean ± SEM frequency of mIPSCs in CeA neurons from msP rats with or without ethanol history. Basal spontaneous CeA GABAergic transmission is significantly (*p< 0.05) enhanced in msP rats exposed to ethanol drinking via two bottle choice paradigm (designated as 2BC) compared to age-matched alcohol naïve msP (designated as naïve msP) rats. B: Mean ± SEM amplitude of mIPSCs in CeA neurons from naïve msP and 2BC msP rats. C: Ethanol significantly (*p< 0.05; Student’s t-test) increased the mean mIPSC frequency in each group. The ethanol effect was comparable in the two groups (p > 0.05; unpaired t-test). D: Representative mIPSC recordings in CeA neurons from ethanol naive msP (left) and ethanol exposed msP (right) rats. E: Cumulative frequency histogram for the representative CeA neurons of D showing a shift to the left, indicating a shorter inter-event interval (higher frequencies) during the application of 44 mM ethanol in both naïve msP (left panel) and 2BC msP (right panel) rat. Note that in the CeA neuron from the ethanol exposed msP rat, the control inter-event interval is shorter (higher frequencies) than that from naïve msP rat.