Table 1.
Mouse Brg1 allelic series
| Mutant Allele | Tissue(s) | Phenotype | Reference(s) |
|---|---|---|---|
| Null (constitutive) | All | −/− peri-implantation lethality +/− exencephaly and mammary tumors with incomplete penetrance |
Bultman et al. 2000 Bultman et al. 2008 |
| ENU1 (constitutive) Hypomorph (E1083G) | All | Null/ENU1 E12.5 lethality, anemia associated with globin and replication defects ENU1/ENU1 post-natal failure to thrive |
Bultman et al. 2005 Kim et al. 2007, 2009a, 2009b Cohen et al. 2010 |
| Zp3-Cre | Oocytes | Maternal effect: progeny exhibit 2-cell arrest associated with ZGA defect | Bultman et al. 2006 |
| Tie2-Cre | VECs | E11.5 lethality associated with yolk sac angiogenesis defects |
Griffin et al. 2008, 2011 Stankunas et al. 2008 Curtis and Griffin 2012 |
| Lck-Cre | T cells | DN-DP block in thymus, CD4 derepression, intestinal inflammation |
Gebuhr et al. 2003 Chi et al. 2003 |
| Lck-Cre Knock-in Antimorph (K785R) | T cells | T cell defect with similarities and differences compared to conditional null | Jani et al. 2008 |
| Nestin-Cre | Neuronal progenitors | Neuronal differentiation defects and early postnatal lethality |
Matsumoto et al. 2006 Lessard et al. 2007 |
| Sm22α-Cre | Cardiomyocytes | Lethality just after E11.5 associated with proliferation defect; inducible mutation prevents MHC switch from occurring in adults in response to hypertrophy | Hang et al. 2010 |
| Nkx2.5-Cre | Cardiomyocytes | Cardiac defects with lethality mostly at E10.5 but with some survivors | Takeuchi et al. 2011 |
| Mhv-Cre | Germ cells | Synaptic defects and meiotic arrest of spermatocytes | Kim et al. 2012 |
| Mx1-Cre | VEC, HSC, liver | Lethal cardiovascular defect within ~1 month of mutation induction if also Brm−/− | Willis et al. 2012 |
| Wap-Cre | Mammary, ovary, uterus | No mammary tumors but ovarian cysts and uterine tumors | Serber et al. 2012 |
| K14-Cre | Keratinocytes and epithelial cells | Peri-natal lethality due to dehydration from skin barrier permeability impairment; limb malformations due to AER defect during development | Indra et al. 2005 |
| Dhh-Cre | Schwann cells | Neuropathy due to Schwann cell differentiation and myelination defect | Welder et al. 2012 |
| Le-Cre | Eye | Microphthalmia and other eye defects | He et al. 2010 |
| smMHC-Cre | Smooth muscle | Lethality associated with smooth muscle defects in cardiovascular, pulmonary, and other sites including GI tract | Zhang et al. 2012 |
-Note: does not include RNAi experiments or expression of dominant-negative BRG1 in tissue-culture cells including ES cells, which have been important for showing a role in processes such as pluripotency and muscle cell differentiation (for example, de la Serna et al. 2001).
-All mutant alleles are conditional nulls unless indicated otherwise.
-Abbreviations: ZGA, zygotic genome activation; VEC, vascular endothelial cell; DN, double negative (CD4−CD8−); DP, double positive (CD4+CD8+); MHC, myosin; heavy chain; HSC, hematopoitic stem cells; AER, apical ectodermal ridge; consult references for gene names of promoters used to drive Cre.