Table 4.
Genotype | Expected^ | Observed# | Observed/Expected | |
---|---|---|---|---|
Brg1 | Brm | |||
+/+ | +/+ | 1/12 (.083) | 21 (.150) | 1.8** |
+/+ | +/− | 2/12 (.167) | 31 (.221) | 1.3 |
+/+ | −/− | 1/12 (.083) | 14 (.100) | 1.2 |
+/− | +/+ | 2/12 (.167) | 21 (.150) | 0.90 |
+/− | +/− | 4/12 (.333) | 39 (.279) | 0.84 |
+/− | −/− | 2/12 (.167) | 14 (.100) | 0.60* |
A total of 140 embryos were genotyped. 11 empty deciduae were observed that could not be genotyped due to maternal contamination.
Because Brg1−/− is lethal prior to implantation, no embryos were observed for this genotype regardless of Brm genotype (+/+, +/−, or −/−), and the absence of these mice were taken into account when determining the expected genotypic frequencies.
p < 0.05 and
p < 0.005 based on chi-squared goodness-of-fit statistical tests.