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. 2013 Jan 15;4:1350. doi: 10.1038/ncomms2356

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(a,b) Cumulative probability of first opening to each individual conductance level during activation from -60 to 0 mV (maximum probability increases with voltage). The reduction of the maximum from unity reflects the probability of observing a null sweep with no channel activity. Note expanded time scale in b. (c) Summary of the weighted time constants from biexponential fits to the cumulative probability of first opening for each individual conductance level and for opening to any level. (d) A comparison of the cumulative probability of first opening for Nav1.4 and Nav1.4-WCW during the first 20 ms of activation at 0 mV. Smooth lines are biexponential fits. (e) Comparison of the average single-channel response scaled to the observed peak open probability during activation at 0 mV for Nav1.4 (solid black) and Nav1.4-WCW (red). The response for Nav1.4 is also shown after normalizing to the peak response for Nav1.4-WCW (dotted black).