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CpG ODN enhances and chitosan reduces in vivo tumor protection and survival generated by adenovirus cancer vaccines. C57BL/6 mice were challenged subcutaneously with E.G7-OVA (upper two panels) or parental EL4 (bottom panel) tumor cells 14 days after adenovirus immunization. (a) Tumor volume and (b,c) percent survival were determined over time. Means ± SEM are shown and numbers in parentheses (upper panel) indicate tumor incidence.
