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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Clin Perinatol. 2012 Mar;39(1):149–164. doi: 10.1016/j.clp.2011.12.006

Fig. 3.

Fig. 3

Response to intravenous sildenafil. Seven infants were treated with open-label intravenous sildenafil before initiation of iNO. Oxygenation index was improved by 1 hour (24.6 ± 4.6 to 16.1 ± 9.9; *P = .0502), with significant and sustained improvement by 4 hours after initiation of sildenafil (14.7 ± 6.4; †P = .0088). Only one infant went on to require therapy with iNO. (From Steinhorn RH, Kinsella JP, Butrous G, et al. Open-label, multicentre, pharmacokinetic study of iv sildenafil in the treatment of neonates with persistent pulmonary hypertension of the newborn (PPHN). Circulation 2007;116:II-614; with permission.)