. Author manuscript; available in PMC: 2013 Mar 1.

Published in final edited form as: Clin Perinatol. 2012 Mar;39(1):149–164. doi: 10.1016/j.clp.2011.12.006

Table 1.

Summary of the large, multicenter, randomized trials of iNO in term newborns with hypoxemic respiratory failure or PPHN, showing the effect of iNO on ECMO use, mortality, and neurodevelopmental impairment

		Initial Oxygenation Index	% ECMO		% Mortality		% Neurodevelopmental Impairment
Study	N	Initial Oxygenation Index	Control	iNO	Control	iNO	Control	iNO
Neonatal Inhaled	235	44	55	39^*	17	14	30	35
Nitric Oxide
Study Group¹⁹

Roberts et al⁷⁵	58	44.4	71	40^*	7	7	–	–

Clark et al^76,77	248	39	65	48^*	8	7	14	19

Davidson et al²²	155	24.7	34	22	2	8	20	18

Konduri et al^15,16	299	19.2	12	10	9	7	25	28

P<.05; significant reduction.