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. 2013 Jan 15;2013:878237. doi: 10.1155/2013/878237

Table 2.

Followup information from individuals with TDR associated with ARV resistance.

IDa HIV exposureb Agec/genderd ART regimene CD4+ T cells Viral load Time to last
VL/CD4 testj
Resistance mutations
(CPR)k
Resistance mutations
(IAS)l
Subtypem
(cells/mm3) (Log10)
Before ARTf Last testg Before ARTh Last testi
BR08SP441 MSM 25/M TDF/3TC/EFV 312 311 4.40 4.78 N.A E138A B
BR09SP005 MSM 41/M AZT/3TC/LPV 388 1025 4.77 <1.70 13 months E138A B
BR09CA065 MSM 37/M TDF/3TC/EFV 248 641 4.43 <1.70 8 months V82I B
BR09CA067 MSM 38/M AZT/3TC/EFV 244 817 4.58 <1.70 31 months V82I B
BR09CA071 MSM 29/M 487 562 3.58 2.61 K103N K103N B
BR09CA075 WSM 66/F AZT/3TC/EFV 224 378 5.70 <1.70 18 months E138A B
BR09CA091 MSM 30/M TDF/3TC/LPV/r 260 384 4.94 <1.70 26 months K103N K103N B
BR09CA097 WSM 40/F 567 567 4.18 4.18 G190A G190A B
BR09CA175 MSM 29/M AZT/3TC/ATV/r 283 164 3.76 3.58 No supression K103N K103N B
BR09CA190 WSM 32/F AZT/3TC/EFV 207 609 4.47 <1.70 37 months E138A B
BR09CA192 MSM 29/M 751 686 3.74 4.25 K103N K103N B
BR09CA194 IDU+MSM 34/M N.A. 230 230 <1.70 N.A. Q58E B
BR09CA210 MSM 22/M 741 636 5.19 4.90 M41L, T215E M41L B
BR09CA262 IGN 29/F N.A. 217 209 5.45 5.24 V82I/E138A C
BR09CA264 MSM 39/M AZT/3TC/EFV 243 629 4.78 <1.70 37 months V82I B
BR09CA271 MSM 29/M TDF/3TC/EFV 197 557 4.50 <1.70 26 months M41L M41L B
BR09CA296 MSM 26/M TDF/3TC/LPV/r 221 723 3.95 <1.70 29 months K103N K103N B
BR09CA298 MSW 26/M 731 668 4.00 4.65 M230L M230L B
BR09CA300 MSM 21/M 1062 729 3.29 3.20 V82I B
BR09SP310 MSM 27/M TDF/3TC/RAL 108 955 5.55 <1.70 15 months E138A B
BR09CA343 MSM 34/M AZT/3TC/EFV 335 388 4.41 <1.70 35 months E138A B
BR09CA344 WSM 39/F 381 454 3.81 4.42 K101P, K103S K101P, K103S B
BR09CA355 WSM 53/F TDF/3TC/EFV 318 787 3.52 <1.70 27 months L90M L90M B
BR09CA369 MSW 58/M TDF/3TC/EFV 348 348 4.76 N.A E138A BF
BR09SP588 MSM 33/M 517 441 4.49 4.07 M46I, L90M/K101P, G190A M46I, Q58E, L90M/K101P, G190A B
BR09SP003 pARV+MSM 41/M TDF/3TC/DRV/r/RAL 312 490 4.86 <1.70 3 months M46I, G73S, I84V, L90M/M41L, V75M, F77L, T215D, Y188L M46I, I54V, I84V, L90M/M41L, F77L, Y188L B
BR09CA078 pARV+WSM 40/F AZT/3TC/EFV 297 492 3.57 <1.70 14 months A72V B
BR09CA095 pARV+MSM 32/M 631 658 2.68 3.07 K103N, L90M K103N, L90M B
BR09CA187 pARV+WSM 25/F 656 592 3.93 4.24 V82I B
BR09CA280 pARV 28/M 632 395 3.61 4.19 K103N K103N B
BR09CA372 pARV+MSM 29/M TDF/3TC/ATV/r 273 774 4.73 <1.70 37 months K103N K103N B
BR09CA197 pARV+WSM 47/F N.A. N.A. N.A. N.A. T215S, I85V B
BR09SP253 pARV+WSM 47/F 1142 1334 2.06 2.70 V82I B

aSamples ID (BR from Brazil, 09 for year of collection, and CA or SP for clinical site and samples number).

bExposure as MSM men that refers to sex with other men, WSM for women that refers to sex with men, IDU for intravenous drug use, and pARV for patients referring to sex with one or more partners using antiretroviral therapy.

cAge in years, dgender as M for male, and F for female.

eART treatment as first regimen or no treatment.

fCD4+ T cells prior to treatment start (pre-ART) and glast CD4 available (bold for CD4 values higher than pre-ART, when ARV was taken);

hViral load prior to ART (before ART) and ilast VL available. (bold for undetectable viral copies/mL, <1.70 log10, when ARV was taken).

jTime since treatment initiation until last CD4/VL determination in months.

k,lResistance mutations observed (Stanford CPR and 2011 IAS list).

mViral subtype at pol region.

N.A. for data not available.