Table 2.
IDa | HIV exposureb | Agec/genderd | ART regimene | CD4+ T cells | Viral load |
Time to last VL/CD4 testj |
Resistance mutations (CPR)k |
Resistance mutations (IAS)l |
Subtypem | ||
---|---|---|---|---|---|---|---|---|---|---|---|
(cells/mm3) | (Log10) | ||||||||||
Before ARTf | Last testg | Before ARTh | Last testi | ||||||||
BR08SP441 | MSM | 25/M | TDF/3TC/EFV | 312 | 311 | 4.40 | 4.78 | N.A | E138A | B | |
BR09SP005 | MSM | 41/M | AZT/3TC/LPV | 388 | 1025 | 4.77 | <1.70 | 13 months | E138A | B | |
BR09CA065 | MSM | 37/M | TDF/3TC/EFV | 248 | 641 | 4.43 | <1.70 | 8 months | V82I | B | |
BR09CA067 | MSM | 38/M | AZT/3TC/EFV | 244 | 817 | 4.58 | <1.70 | 31 months | V82I | B | |
BR09CA071 | MSM | 29/M | — | 487 | 562 | 3.58 | 2.61 | — | K103N | K103N | B |
BR09CA075 | WSM | 66/F | AZT/3TC/EFV | 224 | 378 | 5.70 | <1.70 | 18 months | E138A | B | |
BR09CA091 | MSM | 30/M | TDF/3TC/LPV/r | 260 | 384 | 4.94 | <1.70 | 26 months | K103N | K103N | B |
BR09CA097 | WSM | 40/F | — | 567 | 567 | 4.18 | 4.18 | — | G190A | G190A | B |
BR09CA175 | MSM | 29/M | AZT/3TC/ATV/r | 283 | 164 | 3.76 | 3.58 | No supression | K103N | K103N | B |
BR09CA190 | WSM | 32/F | AZT/3TC/EFV | 207 | 609 | 4.47 | <1.70 | 37 months | E138A | B | |
BR09CA192 | MSM | 29/M | — | 751 | 686 | 3.74 | 4.25 | — | K103N | K103N | B |
BR09CA194 | IDU+MSM | 34/M | N.A. | 230 | 230 | — | <1.70 | N.A. | Q58E | B | |
BR09CA210 | MSM | 22/M | — | 741 | 636 | 5.19 | 4.90 | — | M41L, T215E | M41L | B |
BR09CA262 | IGN | 29/F | N.A. | 217 | 209 | 5.45 | 5.24 | — | V82I/E138A | C | |
BR09CA264 | MSM | 39/M | AZT/3TC/EFV | 243 | 629 | 4.78 | <1.70 | 37 months | V82I | B | |
BR09CA271 | MSM | 29/M | TDF/3TC/EFV | 197 | 557 | 4.50 | <1.70 | 26 months | M41L | M41L | B |
BR09CA296 | MSM | 26/M | TDF/3TC/LPV/r | 221 | 723 | 3.95 | <1.70 | 29 months | K103N | K103N | B |
BR09CA298 | MSW | 26/M | — | 731 | 668 | 4.00 | 4.65 | — | M230L | M230L | B |
BR09CA300 | MSM | 21/M | — | 1062 | 729 | 3.29 | 3.20 | — | V82I | B | |
BR09SP310 | MSM | 27/M | TDF/3TC/RAL | 108 | 955 | 5.55 | <1.70 | 15 months | E138A | B | |
BR09CA343 | MSM | 34/M | AZT/3TC/EFV | 335 | 388 | 4.41 | <1.70 | 35 months | E138A | B | |
BR09CA344 | WSM | 39/F | — | 381 | 454 | 3.81 | 4.42 | — | K101P, K103S | K101P, K103S | B |
BR09CA355 | WSM | 53/F | TDF/3TC/EFV | 318 | 787 | 3.52 | <1.70 | 27 months | L90M | L90M | B |
BR09CA369 | MSW | 58/M | TDF/3TC/EFV | 348 | 348 | 4.76 | — | N.A | E138A | BF | |
BR09SP588 | MSM | 33/M | — | 517 | 441 | 4.49 | 4.07 | — | M46I, L90M/K101P, G190A | M46I, Q58E, L90M/K101P, G190A | B |
BR09SP003 | pARV+MSM | 41/M | TDF/3TC/DRV/r/RAL | 312 | 490 | 4.86 | <1.70 | 3 months | M46I, G73S, I84V, L90M/M41L, V75M, F77L, T215D, Y188L | M46I, I54V, I84V, L90M/M41L, F77L, Y188L | B |
BR09CA078 | pARV+WSM | 40/F | AZT/3TC/EFV | 297 | 492 | 3.57 | <1.70 | 14 months | A72V | B | |
BR09CA095 | pARV+MSM | 32/M | — | 631 | 658 | 2.68 | 3.07 | — | K103N, L90M | K103N, L90M | B |
BR09CA187 | pARV+WSM | 25/F | — | 656 | 592 | 3.93 | 4.24 | — | V82I | B | |
BR09CA280 | pARV | 28/M | — | 632 | 395 | 3.61 | 4.19 | — | K103N | K103N | B |
BR09CA372 | pARV+MSM | 29/M | TDF/3TC/ATV/r | 273 | 774 | 4.73 | <1.70 | 37 months | K103N | K103N | B |
BR09CA197 | pARV+WSM | 47/F | — | N.A. | N.A. | N.A. | N.A. | — | T215S, I85V | B | |
BR09SP253 | pARV+WSM | 47/F | — | 1142 | 1334 | 2.06 | 2.70 | V82I | B |
aSamples ID (BR from Brazil, 09 for year of collection, and CA or SP for clinical site and samples number).
bExposure as MSM men that refers to sex with other men, WSM for women that refers to sex with men, IDU for intravenous drug use, and pARV for patients referring to sex with one or more partners using antiretroviral therapy.
cAge in years, dgender as M for male, and F for female.
eART treatment as first regimen or no treatment.
fCD4+ T cells prior to treatment start (pre-ART) and glast CD4 available (bold for CD4 values higher than pre-ART, when ARV was taken);
hViral load prior to ART (before ART) and ilast VL available. (bold for undetectable viral copies/mL, <1.70 log10, when ARV was taken).
jTime since treatment initiation until last CD4/VL determination in months.
k,lResistance mutations observed (Stanford CPR and 2011 IAS list).
mViral subtype at pol region.
N.A. for data not available.