Table 2. Soft tissue tumors and commonly associated immunohistochemical (IHC) markers.

	Positive IHC markers	Negative IHC markers
Leiomyosarcoma	vimentin, actin, myosin, desmin, H-caldesmon	CD34, CD117, K-RAS
Rhabdomyosarcoma embryonal	Myogenin, myoD1, Sarcomeric actin, myosin, desminvimentin, but alpha actinin, z-protein and titin are more specific
Rhabdomyosarcoma alveolar	As emberyonal type plus antiskeletal muscle antibodies, both have ankyrin-repeated protein Arpp/Carp
Angiosarcoma	CD31, CD34, CAM 5.2 (epithelioid variant), vWF, Factor VIII, BNH9
Malignant fibrous histocytoma	according to IHC markings should be categorized/regrouped under any of the other type-specific sarcoma groups and if not then labeled as Undifferentiated
Dermatofibrosarcoma protuberans	Vimentin, CD34, Focal actin	Factor XIIIa, keratin, S100
Solitary fibrous tumor	CD34, vimentin, Bcl2, occasionally desmin	Keratin, S100
Shwannoma	S100, vimentin, rarely CD34	Actin, desmin, CD117, GFAP

IHC, Immunohistochemical; CD, Cluster differentiation molecule; myoD1, myogenic differentiation 1; Arpp, ankyrin-repeated protein with PEST and proline rich region; Carp, Cardiac ankyrin repeated protein; CAM, Cell Adhesion Molecule; vWF, von Willebrand Factor; BNH9, Monocolonal antibody BNH9; K-RAS, Kristen Rat Sarcoma viral oncogene homolog; Bcl2, B-Cell lymphoma2; GFAP, Glial Fibrillary Acidic Protein