Table 2.
Identified pharmacogenes in ADHD and asthma.
| Gene | Variants | |
|---|---|---|
| Asthma | ADRB2 | p.Arg16Gly, p.Gln27Glu |
| AC9 | p.Ile772Met | |
| CRHR1 | c.122-1310C > A (intronic) | |
| TBX21 | p.His33Gln | |
| LTC4S | g.24030224A > C (promotor) | |
| CYSLTR1 | p.Phe309Phe | |
| ALOX5 | 5′ UTR | |
| GSDML | c.236-1199G > A (intronic) | |
|
| ||
| ADHD | DRD4 | 48 bp allele |
| DAT1 | 3′ UTR | |
| 5-HTT | del-1212-1255 (promotor) | |
| SNAP-25 | 3′ UTR | |
| COMT | p.Val158Met | |
| ADRA2A | g.31585029G > C | |
ADRB2: agonists of beta-2 adrenergic receptor; AC9: adenylyl cyclase type 9; CRHR1: corticotropin releasing hormone receptor 1; TBX21: T-box 21; LTC4S: leukotriene C4 synthase; CYSLTR1: cysteinyl leukotriene receptor 1; ALOX5: arachidonate 5-lipoxygenase; GSDML: gasdermin B; DRD4: dopamine receptor 4; DAT1: dopamine transporter 1; 5-HTT: serotonin transporter; SNAP-25: synaptosomal-associated protein; COMT: catechol-O-methyltransferase; ADRA2A: adrenergic alpha2-receptor; UTR: untranslated region.