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. Author manuscript; available in PMC: 2013 Jun 14.
Published in final edited form as: Mol Cell. 2012 Nov 8;48(5):760–770. doi: 10.1016/j.molcel.2012.10.002

Figure 3. Many miRNA-dependent sites do not contain seed matches.

Figure 3

(a) Proportion of sites from all AGO binding sites or from miR-155-dependent sites that do not contain seed matches. (b-c) Examples of non-canonical targets. Dotted black vertical lines indicate the location of a seed-like site in the site. Predicted base-pairing between miR-155 and 3′UTR sequences are indicated below AGO dCLIP read distribution profiles. Positions selected for mutations in luciferase reporter constructs are highlighted in the alignment. (c) Example of a gene with both a non-canonical and a canonical site in the same 3′UTR; numbers along the horizontal axis indicate nucleotides from the start of the 3′UTR.