Table 1.
GO enrichment analysis. The targets of miRNAs defined by seed matches in AGO CLIP binding sites in T cells were queried for enrichment in Gene Ontology immune processes. All functions with (p<0.005) using a Hypergeometric test are listed.
| miRNA | Immune Process | Targets |
|---|---|---|
| miR-155 | Negative regulation of B cell proliferation | BTLA, INPP5D, RC3H1 |
| miR-155 | Lymphocyte homeostasis | AHR, BCL2, CASP3, HIF1A, MEF2C, PMAIP1, SKIL |
| miR-21 | Alpha-beta T cell differentiation | BCL11B, BCL2, SATB1, STAT6, TCF7 |
| miR-21 | Thymus development | BCL11B, BCL2, BCL2L11, CCNB2, CITED2, JARID2 |
| miR-146 | Enucleate erythrocyte differentiation | ID2, SP1, SP3 |
| miR-146 | Positive regulation of Th1 differentiation | CCR7, SOCS5 |
| miR- 17~92 |
Embryonic hemopoiesis | GATA3, HIF1A, MLL1, RUNX1, TGFBR2 |
| miR- 17~92 |
Negative regulation of T cell proliferation | BTLA, CBLB, CD274, IL2RA, ITCH, PDCD1LG2, RC3H1 |