Table 1.
Initial GWAS and follow-up studies of blood pressure and hypertension status (ND = not done).
| Authors | PubMed ID | Population | n | Trait | SNP's typed | SNP/Gene associated | Metaanalysis | max GWAS p value | Effect size (mm Hg) |
Replication | Replic result |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Wang et al | 19114657 | Amish | 542 | BP | 80K | rs4977950 | Y | 9.1 × 10−8 | 3.3 | Y | confirmed |
| STK39 (cluster of SNPs) | Y | 8.9 × 10−6 | |||||||||
| Cunnington et al | 20003416 | British caucasians | 1372 | BP | 3 | STK39 | N | NS | none | ND | |
| Org et al | 19304780 | Europeans | 1017 | Hyp | 1017 | CDH13 | Y | 5.3 × 10−8 | 1.6 | Y | marginal |
| Cho et al | 19396169 | Asians | 8842 | BP | 352K | rs17249754/ATB2B1 | N | 9.1 × 10−7 | 1.3 | Y | confirmed |
| rs715987 | N | 4.5 × 10−6 | 1.6 | Y | not confirmed | ||||||
| Adeyemo et al | 19609347 | African Americans | 1017 | BP/Hyp | 800K | rs5743185/PMS1 | 2.1 × 10−11 | ~5–6 | ND | ||
| rs16877320 | 3.4 × 10−9 | Y | not confirmed | ||||||||
| rs11160059/SLC24A4 | 1.5 × 10−8 | Y | not confirmed | ||||||||
| rs17365948/YWHAZ | 1.6 × 10−8 | Y | not confirmed | ||||||||
| rs12279202/IPO7 | 4.8 × 10−8 | ND | |||||||||
| rs3751664/CACNA1H | 6.7 × 10−8 | ND |