Table 2.

Summarized Findings in Two Large Scale GWAS studies of blood pressure and hypertension status (modified from www.genome.gov/gwastudies). Replicated genes are shown in bold.

First Author	PubMed ID	Trait/Disease	Initial Sample Size	Replication Sample Size	Region	Reported Gene(s)	Strongest SNP-Risk Allele	Risk Allele Frequency in Controls	P-value	Odds ratio or beta-coefficient and [95% CI]
Newton-Cheh	19430483	Diastolic BP	34,433	100,347 Europeans,	15q24.1	CYP1A1, CYP1A2, CSK, LMAN1L, CPLX3, ARID3B	rs1378942-C	0.36	1 × 10−23	0.43 [0.35–0.51] mm Hg increase
				12,889 Indian Asian	4q21.21	FGF5, PRDM8, c4orf22	rs16998073-T	0.21	1 × 10−21	0.5 [0.40–0.60] mm Hg increase
					12q24.12	ATXN2, SH2B3	rs653178-T	0.53	3 × 10−18	0.46 [0.36–0.56] mm Hg decrease
					10q21.2	c10orf107, TMEM26, RTKN2, RHOBTB1, ARID5B	rs1530440-T	0.19	1 × 10−9	0.39 [0.27–0.51] mm Hg decrease
					17q21.32	ZNF652, PHB	rs16948048-G	0.39	5 × 10−9	0.31 [0.21–0.41] mm Hg increase
					3q26.2	MDS1	rs1918974-T	0.54	8 × 10−8	0.27 [0.17–0.37] mm Hg decrease
		Systolic BP	34,433	100,347 Europeans	10q24.32	CYP17A1, AS3MT, CNNM2, NT5C2	rs11191548-T	0.91	7 × 10−24	1.16 [0.92–1.40] mm Hg increase
				12,889 Indian Asian	1p36.22	MTHFR, NPPA, CLCN6, NPPB, AGTRAP	rs17367504-G	0.14	2 × 10−13	0.85 [0.63–1.07] mm Hg decrease
					17q21.31	PLCD3, ACBD4, HEXIM1, HEXIM2	rs12946454-T	0.28	1 × 10−8	0.57 [0.37–0.77] mm Hg increase
Levy	19430479	Diastolic BP	29,136	34,433	12q24.12	SH2B3	rs3184504-T	0.48	3 × 10−14	0.48 [0.36–0.60] mm Hg increase
					15q24.1	CSK, ULK3	rs6495122-A	0.42	2 × 10−10	0.4 [0.28–0.52] mm Hg increase
					12q21.33	ATP2B1	rs2681472-A	0.83	1 × 10−9	0.5 [0.34–0.66] mm Hg increase
					3p22.1	ULK4	rs9815354-A	0.17	3 × 10−9	0.49 [0.33–0.65] mm Hg increase
					10p12.33	CACNB2	rs11014166-A	0.66	1 × 10−8	0.37 [0.25–0.49] mm Hg increase
					12q24.21	TBX3, TBX5	rs2384550-A	0.35	4 × 10−8	0.35 [0.23–0.47] mm Hg decrease
					11p15.1	PLEKHA7	rs11024074-T	0.72	1 × 10−6	0.33 [0.19–0.47] mm Hg decrease
		Systolic BP	29,136	34,433	12q21.33	ATP2B1	rs2681492-T	0.8	4 × 10−11	0.85 [0.60–1.10] mm Hg increase
					10q24.32	CYP17A1	rs1004467-A	0.9	1 × 10−10	1.05 [0.74–1.36] mm Hg increase
					11p15.1	PLEKHA7	rs381815-T	0.26	2 × 10−9	0.65 [0.43–0.87] mm Hg increase
					12q24.12	SH2B3	rs3184504-T	0.48	5 × 10−9	0.58 [0.38–0.78] mm Hg increase
					3q26.2	MDS1	rs448378-A	0.52	1 × 10−7	0.51 [0.31–0.71] mm Hg decrease
					10p12.33	CACNB2	rs11014166-A	0.66	7 × 10−7	0.5 [0.30–0.70] mm Hg increase
					1p36.22	CASZ1	rs12046278-T	0.64	5 × 10−6	0.53 [0.29–0.77] mm Hg decrease
		Hypertension	29,136	34,433	12q21.33	ATP2B1	rs2681472-A	0.83	2 × 10−11	0.15 [0.11–0.19] increase in log odds
					10p12.33	CACNB2	rs11014166-A	0.66	6 × 10−8	0.09 [0.05–0.13] increase in log odds
					20q13.32	ZNF831, EDN3	rs16982520-A	0.88	2 × 10−7	0.13 [0.09–0.17] decrease in log odds
					8p23.1	MSRA	rs11775334-A	0.32	4 × 10−6	0.08 [0.04–0.12] increase in log odds