Table 2.
Adjusted and unadjusted association results for rs188140481[A] and prostate cancer
| Unadjusted |
Adjusted |
|||
|---|---|---|---|---|
| Study group | OR (95% CI) | P value | OR (95% CI) | P value |
| Iceland | 3.01 (2.23, 4.06) | 5.9×10−13 | 2.04 (1.42, 2.92) | 1.0×10−4 |
| Chicago | 2.63 (1.50, 4.60) | 7.0×10−4 | 1.95 (1.07, 3.56) | 0.029 |
| The Netherlands | 2.67 (1.73, 4.13) | 1.0×10−5 | 1.93 (1.21, 3.08) | 0.006 |
| Romania | 2.52 (0.90, 7.09) | 0.08 | 2.06 (0.71, 5.97) | 0.18 |
| Spain | 3.3 (0.95, 11.45) | 0.06 | 3.31 (0.92, 11.86) | 0.066 |
| UK | 4.22 (2.24, 7.96) | 8.8×10−6 | 3.20 (1.66, 6.15) | 4.9×10−4 |
| All combined | 2.97 (2.42, 3.65) | 3.4×10−25 | 2.15 (1.71, 2.70) | 7.0×10−11 |
| Phet = 0.89 | I2 = 0.0 | Phet = 0.81 | I2 = 0.0 | |
Shown are association results (the allelic odds-ratio (OR) with 95% confidence interval (95% CI) and P value) for rs188140481 adjusted and unadjusted for the 9 previously published anchor prostate cancer risk SNPs in populations of European descent and located on 8q24 (rs1254366314, rs1008690811,14, rs101634314, rs1325229814, rs169019798, rs1690209412, rs44511412/rs62086113,14, rs69832679, rs14472957). Only individuals directly genotyped for rs188140481 were used in this analysis.