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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Expert Rev Vaccines. 2012 Sep;11(9):1087–1101. doi: 10.1586/erv.12.84

Figure 4. Phylogenetic tree of chikungunya virus strains derived from complete concatenated open reading frames for the nonstructural and structural polyproteins.

Figure 4

Key E1 amino acid substitutions that facilitated (Indian Ocean lineage) or prevented (Asian lineage) adaptation to Aedes albopictus are shown on the right.

CAR: Central African republic; ECSA: East/Central/South Africa.