Table 1.
Class Comparisons of Three-Dimensional Microdissected Intratumor Subregions
| Comparison | Comparison definition∗ | Differentially expressed genes (No.) |
|
|---|---|---|---|
| P < 0.001 | Fold change ≥2 | ||
| X-Y dimension | |||
| A1 | T1-1 vs T1-2 at level A | 24 | 1 |
| A2 | (T1-1 + T1-2) vs T2 at level A | 10 | 0 |
| A3 | (T1-1 + T1-2) vs T3 at level A | 5 | 0 |
| A4 | T2 vs T3 at level A | 3 | 0 |
| C1 | T1-1 vs T1-2 at level C | 2 | 0 |
| C2 | (T1-1 + T1-2) vs T2 at level C | 30 | 0 |
| C3 | (T1-1 + T1-2) vs T3 at level C | 33 | 0 |
| C4 | T2 vs T3 at level C | 21 | 0 |
| AC1 | T1-1 vs T1-2 across level A and B | 7 | 0 |
| AC2 | (T1-1 + T1-2) vs T2 across level A and B | 19 | 0 |
| AC3 | (T1-1 + T1-2) vs T3 across level A and B | 24 | 0 |
| AC4 | T2 vs T3 across level A and B | 10 | 0 |
| Z dimension | |||
| V1.1 | T1-1 at level A vs T1-1 at level C | 32 | 2 |
| V1.2 | T1-2 at level A vs T1-2 at level C | 10 | 0 |
| V2 | T2 at level A vs T2 at level C | 54 | 4 |
| V3 | T3 at level A vs T3 at level C | 27 | 0 |
| Overall difference between level A and level C | 93 | 0 | |
∗
Tumor subregions (T) and levels (A–C) are as shown in Figure 1B.