Fig. 6.

TIPOC serves as a “hub” for polarized growth. The long, coiled-coil protein Scy directly interacts with DivIVA and FilP at hyphal tips. DivIVA directly controls cell wall synthesis (PBP), whereas Scy is responsible for the organization of the TIPOC. The possible link between the cell division machinery (FtsZ, SsgA, SsgB, ParA, and ParB) and the TIPOC is also shown. Other tip-localized proteins include CslA (cellulose synthase), TraB (DNA translocase) and AfsK, the kinase that can phosphorylate DivIVA. CM, cell membrane; PG, peptidoglycan.