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. 2013 Jan 14;110(5):1923–1928. doi: 10.1073/pnas.1221742110

Fig. 5.

Fig. 5.

Expression of ΔFosB in D1 but not D2 NAc MSNs promotes behavioral responses to cocaine. (A–D) Locomotor response to saline (triangles) or cocaine (squares) was measured daily in animals expressing GFP alone (open) or GFP and ∆FosB (filled) in D1 (red) or D2 (green) NAc MSNs. Cocaine doses of 3.75 (A and B) and 7.5 mg/kg (C and D) are shown. (n = 6–10 mice in each group; *different from GFP, P < 0.05, one-way ANOVA). (E and F) Cocaine place preference at the indicated dose for animals expressing GFP alone (open) or GFP and ∆FosB (filled) in D1 (red) or D2 (green) NAc MSNs. (n = 6–10 mice in each group; *different from GFP, P < 0.05, two-tailed t test).