Fig. 7.

Functional circadian clock is necessary for correct dermal wound healing. (A) Masson-Goldner trichrome staining of 6-d wounds from WT (Left), per1/per2^mut (Center), and bmal1^−/− mice (Right). D, dermis; E, epidermis; Es, Eschar; F, fibrin; FH, fibroblast hyperproliferation; G, granulation tissue; He, hemorrhage; HE, hyperproliferative epithelium; HF, hair follicle. (Scale bar, 1 mm.) (B) Wound healing subscores of normal healing WT mice compared with per1/per2^mut and bmal1^−/− mice on day 6 after incisional wounding in the dorsal skinfold. Data represent means ± SD (n = 6).