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Aire-PHD2 is essential for most Aire-induced gene expression in MECs. (A) Comparing Aire-WTs with Aire-ΔPHD2’s impact on the Aire-less transcriptome. FC/FC plots of triplicate data comparing iA-WT with Aire-KO (x axis) and iA-ΔPHD2 with Aire-KO (y axis). Red dots indicate some of the transcripts highlighted in B. (B) List of genes impacted less differentially (more than threefold less) by the ΔPHD2 than the KO mutation.
