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. 2013 Jan 9;110(5):1869–1874. doi: 10.1073/pnas.1219456110

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Fig. 1. — CGI-58 ASO treatment decreases adiposity and diet induced weight gain, but causes severe hepatic steatosis. Eight-week-old mice were treated with control or CGI-58 ASO for 8 wk and (A) CGI-58 protein expression was analyzed in the WAT by Western blot. (B) CGI-58 protein expression was analyzed in the liver. (C) Body weight. (D) Fat mass of the epididymal WAT as assessed by ¹H magnetic resonance spectroscopy. (E) Epididymal WAT weight. (F) Lean mass assessed by ¹H magnetic resonance spectroscopy. (G) Hepatic triglyceride content. P value was calculated by two-way ANOVA.