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. 2013 Jan 9;110(5):1869–1874. doi: 10.1073/pnas.1219456110

Fig. 2.

Fig. 2.

Loss of CGI-58 expression prevents diet-induced insulin resistance by increasing hepatic insulin sensitivity. (A) Basal glucose levels in overnight-fasted mice treated with control or CGI-58 ASO for 8 wk. (B) Insulin levels before and after the hyperinsulinemic-euglycemic clamp studies in mice treated with control or CGI-58 ASO for 8 wk. (C) Glucose infusion rates required to maintain euglycemia during the hyperinsulinemic-euglycemic clamp studies. (D) Average of the glucose infusion rates required to maintain euglycemia during the hyperinsulinemic-euglycemic clamp studies during the last 40 min of the clamp. (E) Insulin-stimulated peripheral glucose disposal during the hyperinsulinemic-euglycemic clamp studies. (F) Endogenous glucose production during the hyperinsulinemic-euglycemic clamp studies. (G) Insulin-stimulated suppression of endogenous glucose production during the hyperinsulinemic-euglycemic clamp studies (n = 8–10 per group). P value calculated by two-way ANOVA.