Table 2.

Changes in predialysis blood or serum measurements

Parameter	Oxymetholone (n=19)	Placebo (n=22)	Difference between Groups in the Mean Change from Baseline (95% CI)
Hemoglobin (g/dl)
Baseline	9.1±1.0	10.1±1.1
Week 24	9.3±1.2	10.1±1.3
Change from baseline	0.1±1.1	−0.04±1.2	1.17 (−0.57 to 0.91)
Fasting plasma glucose (mg/dl)
Baseline	77.2±6.7	77.4±12.9
Week 24	77.3±9.4	83.9±26.5
Change from baseline	0.1±8.1	6.5±20.9	−6.37 (−16.25 to 3.51)
Serum urea nitrogen (mg/dl)
Baseline	56.6±12.1	62.7±14.1
Week 24	63.0±16.7	59.0±15.5
Change from baseline	6.4±14.6a	−3.7±14.9	10.03 (0.71–19.35)a
Serum creatinine (mg/dl)
Baseline	11.1±2.7	11.5±1.5
Week 24	12.3±2.9b	11.2±1.9
Change from baseline	1.2±2.8c	−0.3±1.0	1.47 (0.08–2.86)c
Serum albumin (g/dl)
Baseline	3.8±0.3	4.1±0.2
Week 24	3.9±0.3	4.1±0.3
Change from baseline	0.1±0.3	−0.02±0.2	0.09 (−0.09 to 0.27)
Serum AST (U/L)
Baseline	16.2±6.6	13.8±4.9
Week 24	47.8±45.5b	15.3±7.8
Change from baseline	31.7±32.5c	1.5±6.5	30.15 (14.27–46.03)c
Serum ALT (U/L)
Baseline	14.6±6.5	13.1±5.0
Week 24	70.1±71.3b	15.6±7.5
Change from baseline	55.5±50.6c	2.5±6.4	53.02 (28.44–77.56)c
Serum total bilirubin (mg/dl)
Baseline	0.3±0.1	0.3±0.1
Week 24	0.8±1.0	0.3±0.1
Change from baseline	0.5±0.7c	−0.01±0.1	0.47 (0.13–0.81)b
Serum direct bilirubin (mg/dl)
Baseline	0.09±0.02	0.10±0.02
Week 24	0.51±0.77d	0.10±0.06
Change from baseline	0.42±0.54a	0.00±0.04	0.42 (0.16–0.68)a
Number of patients with
AST more than three times the ULN	0 (0.0)	0 (0.0)
ALT more than three times the ULN	2 (9.5)	0 (0.0)
TB>2 mg/dl	3 (14.3)	0 (0.0)	—

Values were all obtained immediately before the onset of a hemodialysis treatment. Data are mean ± SD. CI, confidence interval; AST, aspartate aminotransferase; ALT, alanine aminotransferase; ULN, upper limit of normal; TB, total bilirubin.

^aCompared with placebo: P<0.05.

^bWeek 24 value compared with baseline: P<0.01.

^cCompared with placebo: P<0.01.

^dWeek 24 value compared with baseline: P<0.05.