Table 5.
Changes in serum hormone concentrations
| Parameter | Oxymetholone (n=19) | Placebo (n=22) | Difference between Groups in the Mean Change from Baseline (95% CI) |
|---|---|---|---|
| Serum testosterone (ng/dl) | |||
| Male | |||
| Baseline | 604.9±165.5 | 528.3±176.0 | |
| Week 24 | 247.2±207.8a | 658.1±333.2 | |
| Change from baseline | −357.7±91.3b | 129.8±328.4 | −487.52 (−638.02 to −336.98)b |
| Female | |||
| Baseline | 67.5±40.6 | 95.2±88.3 | |
| Week 24 | 94.2±73.2 | 115.0±116.5 | |
| Change from baseline | 26.7±61.8 | 19.8±30.0 | 6.93 (−25.11 to 38.97) |
| Serum luteinizing hormone (mIU/L) | |||
| Male | |||
| Baseline | 16.4±11.1 | 14.3±9.8 | |
| Week 24 | 10.3±18.5 | 15.6±11.3 | |
| Change from baseline | −6.0±20.4 | 1.3±3.4 | −7.31 (−17.21 to 2.61) |
| Female | |||
| Baseline | 62.4±10.5 | 20.9±23.1 | |
| Week 24 | 74.5±97.0 | 20.9±28.1 | |
| Change from baseline | 12.1±37.1 | 0.0±5.1 | 12.07 (−5.88 to 30.02) |
| Serum prostatic surface antigen in males (ng/ml) | |||
| Baseline | 0.4±0.3 | 0.5±0.3 | |
| Week 24 | 0.3±0.1 | 0.6±0.3a | |
| Change from baseline | −0.1±0.1b | 0.1±0.2 | −0.23 (−0.32 to −0.14)b |
Data are mean ± SD. Normal values for testosterone in men and women are 270–1070 and 6–86 ng/dl, respectively. Normal values for luteinizing hormone in men and women during the reproductive years are 3–15 and 5–22 mIU/L, respectively. CI, confidence interval.
a
Compared with placebo: P<0.05.
b
Compared with placebo: P<0.01.