Table 1.
Baseline risk factors according to presence or absence of doubling of serum creatinine or graft loss during 7 years of follow-up
| Risk Factor | DSCGL (n=438) | No DSCGL (n=1664) | P Value |
|---|---|---|---|
| Categorical variables, n (%) | |||
| Women | 140 (32.0) | 575 (34.6) | 0.34 |
| History of coronary heart disease | 41 (9.4) | 160 (9.6) | 0.93 |
| Diabetes mellitus | 96 (21.9) | 300 (18.0) | 0.07 |
| Smoking | 124 (28.3) | 265 (15.9) | <0.001 |
| History of left ventricular hypertrophy | 71 (16.4) | 240 (14.6) | 0.37 |
| Number of transplants | 0.06 (trend) | ||
| 1 | 364 (83.1) | 1430 (86.0) | |
| 2 | 59 (13.5) | 200 (12.0) | |
| 3 | 15 (3.4) | 33 (2.0) | |
| Hypertension | 348 (79.5) | 1227 (73.7) | 0.02 |
| HLA-DR mismatches | 0.001 (trend) | ||
| 0 | 117 (27.8) | 545 (33.9) | |
| 1 | 214 (50.8) | 825 (51.3) | |
| 2 | 90 (21.4) | 238 (14.8) | |
| Treatment for rejections | 224 (51.7) | 678 (41.3) | <0.001 |
| Continuous variables, mean ± SD | |||
| Age (yr) | 47.4±10.7 | 50.3±10.9 | <0.001 |
| LDL cholesterol (mmol/L) | 4.21±1.06 | 4.12±1.01 | 0.10 |
| HDL cholesterol (mmol/L) | 1.24±0.43 | 1.36±0.45 | <0.001 |
| Triglycerides (mmol/L)a | 2.10±1.48 | 1.90±1.20 | <0.001 |
| Total cholesterol/HDL cholesterol ratio | 5.90±2.36 | 5.28±2.21 | <0.001 |
| Time last transplant (mo)a | 4.96±5.53 | 4.40±4.96 | 0.011 |
| Systolic BP (mmHg) | 149.3± 20.9 | 142.5±18.1 | <0.001 |
| Diastolic BP (mmHg) | 87.2±11.6 | 85.2±9.6 | <0.001 |
| Body mass index (kg/m2) | 25.6±4.8 | 25.9±4.4 | 0.22 |
| Creatinine (μmol/L)a | 170.0±84.0 | 127.0±47.0 | <0.001 |
| Calcium (mmol/L) | 2.41±0.16 | 2.43±0.16 | 0.17 |
| Phosphate (mmol/L) | 1.18±0.27 | 1.15±0.23 | 0.02 |
| Proteinuria (g/24 hr)a | 0.38±0.87 | 0.15±0.24 | <0.001 |
| Hemoglobin (g/dl) (n=1685) | 13.0±1.95 | 13.65±1.73 | 0.007 |
| LnCRP (mg/L) (n=1913) | 1.52±4.66 | 1.43±4.53 | 0.5 |
DSCGL, doubling of serum creatinine or graft loss; LnCRP, natural logarithm of high sensitive C-reactive protein.
a
Median and inter quartile range.