Brain regional 5-HT receptor and transporter binding in outbred diet-induced obese rats. (a) 5-HT2A receptor-specific binding, (b) 5-HT4 receptor-specific binding, and (c) SERT-specific binding in chow-fed control, DIO HF, and DIO chow rats. Data tested with two-way ANOVA with Bonferroni-corrected post-tests. n = 11–12 per group. DIO, diet-induced obese; HF, high fat; SERT, serotonin transporter.