Figure 3.
Brain regional 5-HT receptor and transporter binding in selectively bred polygenic diet-induced obese and diet-resistant rats. (a) 5-HT2A receptor-specific binding, (b) 5-HT4 receptor-specific binding, and (c) SERT-specific binding for pgDIO and pgDR rats. Data tested with three-way ANOVA and subsequent two-way ANOVA with Bonferroni-corrected post-tests, *P < 0.05, **P < 0.01, and ***P < 0.001. For two-way ANOVA analyses and Bonferroni-corrected post-tests, pgDR chow and pgDR HE rats were pooled and pgDIO chow and pgDIO HE rats were pooled. n = 14–16 per group. HE, high energy; pgDIO, polygenic diet-induced obese; pgDR, polygenic diet-resistant; SERT, serotonin transporter.