Table 4.
Select GO Terms Associated with Down-Regulated Genes
| Category | Term | # Genes | p-value |
|---|---|---|---|
| Arsenic | |||
| GOTERM_MF_FAT | GO:0005024~transforming growth factor beta receptor activity | 3 | 2.9E-02 |
| GOTERM_BP_FAT | GO:0043525~positive regulation of neuron apoptosis | 3 | 3.8E-02 |
| GOTERM_BP_FAT | GO:0043123~positive regulation of I-kappaB kinase/NF-kappaB cascade | 5 | 4.8E-02 |
| GOTERM_BP_FAT | GO:0050680~negative regulation of epithelial cell proliferation | 3 | 4.8E-02 |
| Chromium | |||
| GOTERM_BP_FAT | GO:0051270~regulation of cell motion | 23 | 1.2E-06 |
| GOTERM_BP_FAT | GO:0007179~transforming growth factor beta receptor signaling pathway | 12 | 6.5E-06 |
| GOTERM_BP_FAT | GO:0001568~blood vessel development | 24 | 1.7E-05 |
| GOTERM_BP_FAT | GO:0030334~regulation of cell migration | 18 | 9.5E-05 |
| GOTERM_BP_FAT | GO:0008361~regulation of cell size | 19 | 3.5E-04 |
| SP_PIR_KEYWORDS | extracellular matrix | 18 | 3.2E-03 |
| GOTERM_BP_FAT | GO:0043405~regulation of MAP kinase activity | 13 | 3.8E-03 |
| GOTERM_BP_FAT | GO:0045785~positive regulation of cell adhesion | 8 | 4.9E-03 |
| GOTERM_BP_FAT | GO:0042981~regulation of apoptosis | 43 | 6.4E-03 |
| GOTERM_BP_FAT | GO:0048286~lung alveolus development | 5 | 6.7E-03 |
| GOTERM_BP_FAT | GO:0022407~regulation of cell-cell adhesion | 5 | 6.7E-03 |
| GOTERM_BP_FAT | GO:0001666~response to hypoxia | 12 | 8.0E-03 |
| KEGG_PATHWAY | hsa04010:MAPK signaling pathway | 19 | 1.3E-02 |
| KEGG_PATHWAY | hsa05212:Pancreatic cancer | 8 | 2.0E-02 |
| KEGG_PATHWAY | hsa05222:Small cell lung cancer | 8 | 4.3E-02 |
| Nickel | |||
| SP_PIR_KEYWORDS | extracellular matrix | 15 | 1.0E-04 |
| GOTERM_CC_FAT | GO:0031012~extracellular matrix | 19 | 2.0E-04 |
| GOTERM_CC_FAT | GO:0005604~basement membrane | 8 | 9.0E-04 |
| GOTERM_BP_FAT | GO:0045785~positive regulation of cell adhesion | 7 | 1.1E-03 |
| GOTERM_BP_FAT | GO:0007155~cell adhesion | 25 | 5.3E-03 |
| GOTERM_BP_FAT | GO:0051270~regulation of cell motion | 10 | 1.4E-02 |
| GOTERM_BP_FAT | GO:0030199~collagen fibril organization | 4 | 1.9E-02 |
| GOTERM_BP_FAT | GO:0030334~regulation of cell migration | 8 | 5.0E-02 |
| Vanadium | |||
| GOTERM_BP_FAT | GO:0045449~regulation of transcription | 53 | 1.1E-02 |
| GOTERM_MF_FAT | GO:0004629~phospholipase C activity | 4 | 1.2E-02 |
| GOTERM_BP_FAT | GO:0043627~response to estrogen stimulus | 6 | 2.2E-02 |
| GOTERM_BP_FAT | GO:0051092~positive regulation of NF-kappaB TF activity | 4 | 2.4E-02 |
| SP_PIR_KEYWORDS | transcription regulation | 41 | 2.7E-02 |