Table 1.
Factors affecting when GP therapy was initiated in patients with MRSA bacteremia.
| Variable | GP therapy was initiated and stratified according to the timing of preliminary BC indicating SLO growth, No. (%) | P-value | |
|---|---|---|---|
| Before and within 24 h | After 24 h | ||
| No. of patients | 191 (56.2) | 148 (43.8) | |
| Age in years, median (range) | 62 (28–98) | 63 (25–88) | 0.89 |
| Male gender | 111 (58.1) | 103 (69.6) | 0.03 |
| Underlying disease or condition | |||
| Cardiovascular disease | 26 (13.6) | 23 (15.5) | 0.64 |
| Diabetes mellitus | 76 (39.8) | 61 (41.2) | 0.82 |
| Uremia requiring dialysis | 30 (15.7) | 36 (24.3) | 0.05 |
| Decompensated liver cirrhosis | 32 (16.8) | 15 (10.1) | 0.08 |
| Malignancies | 32 (16.8) | 32 (21.6) | 0.26 |
| Prosthetic device implantation | 21 (10.9) | 20 (13.5) | 0.51 |
| Severity-of-illness markera | |||
| Nosocomial acquisition | 141 (73.8) | 104 (70.3) | 0.54 |
| Intensive care unit admission | 51 (26.7) | 24 (16.2) | 0.03 |
| APACHE II score, median (range) | 20 (7–30) | 17 (2–24) | 0.07 |
| APACHE II score > 15 | 34 (17.8) | 10 (6.8) | <0.01 |
| Source of infectionb | |||
| Catheter-related infection | 18 (9.4) | 22 (14.9) | 0.13 |
| Endovascular infection | 3 (1.6) | 6 (4.1) | 0.19 |
| Soft-tissue infection | 55 (28.8) | 43 (29.1) | 1.00 |
| Osteomyelitis | 44 (23.6) | 23 (15.5) | 0.10 |
| Urinary tract infection | 1 (0.5) | 3 (2.0) | 0.32 |
| Pneumonia | 35 (18.3) | 16 (10.8) | 0.07 |
| Primary bacteremia | 46 (24.1) | 28 (18.9) | 0.29 |
BC: blood culture; GP: glycopeptide; MRSA: methicillin-resistant S. aureus; No.: number.
aAt time of blood culture sampling.
bSome patients had more than one infected site.